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Feverfew (Tanacetum parthenium)

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For the most recent studies on the bioactive compounds in Tanacetum parthenium:

Blood. 2005 Jun 1;105(11):4163-9
The sesquiterpene lactone parthenolide induces apoptosis of human acute myelogenous leukemia stem and progenitor cells.
Guzman ML, Rossi RM, Karnischky L, Li X, Peterson DR , Howard DS, Jordan CT.
University of Rochester School of Medicine, 601 Elmwood Ave, Box 703, Rochester, NY 14642, USA. monica_guzman@urmc.rochester.edu

Proc Natl Acad Sci U S A. 2002 Dec 10;99(25):16220-5. Epub 2002 Nov 25.
Preferential induction of apoptosis for primary human leukemic stem cells.
Guzman ML, Swiderski CF, Howard DS, Grimes BA, Rossi RM, Szilvassy SJ , Jordan CT.
Blood and Marrow Transplant Program, Markey Cancer Center, Division of HematologyOncology, University of Kentucky Medical Center, Lexington, KY 40536-0093 USA.

Mol Cancer Ther. 2005 Apr;4(4):587-94.
Parthenolide and sulindac cooperate to mediate growth suppression and inhibit the nuclear factor-kappa B pathway in pancreatic carcinoma cells.
Yip-Schneider MT, Nakshatri H, Sweeney CJ, Marshall MS, Wiebke EA, Schmidt CM.
Department of Surgery, Indiana University School of Medicine, Room 041, Building R4, 1044 West Walnut Street, Indianapolis , IN 46202 , USA . myipschn@iupui.edu

Chem Biol Interact. 2004 Oct 15;149(2-3):165-73.
Microtubule-interfering activity of parthenolide.
Miglietta A, Bozzo F, Gabriel L, Bocca C.
Department of Experimental Medicine and Oncology, University of Torino, Corso Raffaello 30, 10125 Torino , Italy .

Invest New Drugs. 2004 Aug;22(3):299-305.
Phase I dose escalation trial of feverfew with standardized doses of parthenolide in patients with cancer.
Curry EA 3rd, Murry DJ, Yoder C, Fife K, Armstrong V, Nakshatri H, O'Connell M, Sweeney CJ.
Department of Pharmacy Practice, Purdue University, Indianapolis , IN , USA .

This information is intended for educational purposes only and is not intended to replace medical advice. 2/25/2015